Most of these preferences won't need to be changed to use your Koha system, but there are a few that you might want to customize.
If your library uses CAS Authentication, you'll want to set the various CAS system preferences
Administration System Preferences
KohaAdminEmailAddress : This is the email address that will be used by the system in 'from' lines and to send errors to if there is no email set for the branch
noItemTypeImages : Decide if you want to show item type icons in the staff client and opac
delimiter : This value will be put in between fields when exporting data from Koha
virtualshelves : Decide if you want the staff and/or patrons to use lists in Koha
AutoLocation : Require staff to log in to the staff client from a specific IP range
IndependentBranches : Prevent librarians from editing content that belongs to other branches
Go through the Log System Preferences and decide which actions you want to keep track of in the logs
Decide if you'd like to share your library's information with the Koha community by setting the Sharing system preferences.
Decide what cron jobs you need to run and when.