Most of these preferences won't need to be changed to use your Koha system, but there are a few that you might want to customize.
If your library uses CAS Authentication, you'll want to set the various CAS system preferences
Administration System Preferences
KohaAdminEmailAddress : This is the email address that will be used by the system in 'from' lines and to send errors to if there is no email set for the branch
noItemTypeImages : Decide if you want to show item type icons in the staff client and opac
delimiter : This value will be put in between fields when exporting data from Koha
virtualshelves : Decide if you want the staff and/or patrons to use lists in Koha
insecure : If your system is behind a local firewall, you can set it to no require log in for the staff client
AutoLocation : Require staff to log in to the staff client from a specific IP range
IndependantBranches : Prevent librarians from editing content that belongs to other branches
Go through the Log System Preferences and decide which actions you want to keep track of in the logs